CA24166 - Pan-European Network for Inflammaging: A Multi-omics Integration Approach (INFLAMomx)

The prevalence of noncommunicable diseases (NCDs) rises with age, placing a significant burden on public health. As the population ages, an increase in co- and multimorbidity is anticipated, making prevention a key scientific priority at the European level. In recent years, considerable attention has been given to inflammaging, a chronic, low-grade inflammation associated with aging, which contributes to the development of various NCDs, including cardiovascular diseases, neurodegenerative disorders, and metabolic conditions. The primary aim of INFLAMomx is to consolidate resources on NCDs through a Pan-European collaborative network and to investigate them as consequences of inflammaging using cutting-edge multi-omics approaches. This network will unite diverse European expertise across scientific fields (molecular biology, bioinformatics, and healthcare), while fostering collaboration across all career stages. Building upon European research initiatives, INFLAMomx will maximize the use of existing resources, strengthening computational biology and inflammaging research across Europe. The outcomes will enhance understanding of the molecular mechanisms driving inflammaging and its role in the development of NCDs. Furthermore, it will lay the foundation for innovations and translation into clinical practice. A key focus of INFLAMomx is the establishment of standardized guidelines for multi-omics integration methods and the training of the next generation of scientists with an integrative mindset, bridging knowledge gaps between wet lab researchers and computational scientists. Moreover, through targeted dissemination activities aimed at various stakeholders – general public, patient organizations, media, and policymakers – the project will raise awareness about the importance of maintaining health and pave the way for the development of preventive healthcare strategies.